Refer to the factory specs for the Mikunis, and the specs for the exhaust you wish to use. Slip-ons usually don't need mods, they're designed to work with the stock jetting. Full exhausts, with larger tubing from cyl heads to the canister(s) will probably require re-jetting for optimal function. Because of differences in altitude a Kerker 4/1 and a Dynojet Stage 7 kit will be leaner in Denver than in Miami. Richer is safer than leaner, in-that a too-lean carb can cause holed pistons, in an extreme scenario. Detonation ('pinging') is dangerous in that the cyl temps become much-higher, as the fuel charge is ignited ahead of when the spark plug fires.
I know this isn't what you asked-for, but following the manufacturer's directions gets you in the ballpark, and then experience of making changes is your best guide. How does it run after making changes? Using an exhaust gas 'sniffer' is probably the most-scientific way to get data, for most people that means dyno time.
A lot of people including myself have found that going a step or two leaner on the main jet can help, but if you're in Denver, your jetting should be leaner to begin with because of the lesser oxygen density at that altitude. The commonly-expressed delta for air density, from sea level (Miami) to Denver (CO) is 15%. Also, as temperature increases, air density decreases. You can understand why it is very important to prevent going too-lean, as combustion temperatures can spike, causing the fuel to ignite prematurely, (detonation) causing overheating of the piston crown and ring lands, and catastrophic engine component failure.