My two cents is this. the higher the revs the more wear. for example check boats out, I have a 78 Galaxie jet boat that I had to rebuild once I bought it, it had 328 hours when I bought it. In a drive reducing car with transmission going 70 miles an hour thats only around 22,000 miles. Not sure what the official hours are on boats these days but oil changes are alot more numerous as well.
v8s, any internal combustion engine and bike engines although different in size shape etc... they are mechanically simialar, unless your talking about turbines or even a pulse engine which has no moving parts. Back to internal combustion engines, higher revs equals more wear, over revving without a load, bad up keep, and just ragging all have their effects, of course bike engine are made to rev higher to stay in a powerband, you almost have to run 4,000rpm atleast on the max to even do some speed limits. The bike wasn't designed to cruise with big v twins at 90 all day long but rather run 1/4 miles at a drag strip. Out of all the bike I have ever run, keeping in mind I'm not talking about a kawasaki 454 two cylinder, the vmax transmission is geared low for just quick acceleration and not cruising, in my opinion.
Personally I try to cruise around 60-65, which is 3800 to 4300 rpm. Vmax should have been made like the V65 hondas in my view with a large OD gear, the gear is so tall it really doesn't pull like the fitfh gear but rather was designed to keep a steady low rpm cruise.